{"id":678,"date":"2021-08-30T19:15:46","date_gmt":"2021-08-30T19:15:46","guid":{"rendered":"https:\/\/happylungs.flywheelsites.com\/?page_id=678"},"modified":"2024-09-13T10:50:34","modified_gmt":"2024-09-13T14:50:34","slug":"about-ret","status":"publish","type":"page","link":"https:\/\/happylungsproject.org\/about-ret\/","title":{"rendered":"About RET"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” top_padding=”3%” bottom_padding=”3%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][split_line_heading animation_type=”line-reveal-by-space” font_style=”h1″ text_color=”#f68d28″ line_reveal_by_space_text_effect=”none” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”RET-Positive Lung Cancer” text_direction=”default”][\/split_line_heading][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” bottom_padding=”3%” text_color=”dark” text_align=”left” row_border_radius=”10px” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”padding-3-percent” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color=”#f68d28″ background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” font_color=”#ffffff” column_shadow=”none” column_border_radius=”10px” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”5\/6″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][vc_column_text css=”” text_direction=”default”]RET | abbreviation : rearranged during transfection : one of several mutations currently identified as the driver, or underlying cause, of lung cancer.<\/span>[\/vc_column_text][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/6″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” top_padding=”2%” bottom_padding=”0″ text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”10px” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” offset=”vc_col-xs-12″ gradient_type=”default” column_padding_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” column_padding_type=”default” gradient_type=”default”][split_line_heading animation_type=”line-reveal-by-space” font_style=”h3″ text_color=”#111c4e” line_reveal_by_space_text_effect=”none” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”What is RET-Positive Cancer?” text_direction=”default”][\/split_line_heading][divider line_type=”Small Line” line_alignment=”default” line_thickness=”4″ divider_color=”extra-color-1″ custom_line_width=”75″][divider line_type=”No Line” custom_height=”20″][vc_column_text css=”” text_direction=”default”]The RET gene, or rearranged during transfection (RET) gene, is a receptor tyrosine kinase gene that plays an important role in cell growth and differentiation and in the development of nerve cells in the body. RET- positive non-small cell lung cancer is caused by an abnormal re-arrangement or fusion of the RET gene with other fusion gene partners leading to constitutive activation of the RET kinase which produces uncontrolled cell growth and cancer. This alteration basically results in the RET molecule \u201con-off\u201d switch to get stuck in the \u201con\u201d position and causing tumor growth (1). There are different types of RET rearrangements depending on the fusion gene partner. The most common RET fusion gene partner is KIF5B and the second most common is CCDC6 though at least 30 fusion partner genes have been identified to date (2,3). Investigators are currently studying the characteristics of each one in cancer development and treatment.\u00a0<\/span><\/p>\n

RET gene fusions occur most commonly in lung cancer (non-small cell lung cancer) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500\u00a0 cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,4). RET fusion NSCLC seem to be more prevalent in younger patients who have never or rarely smoked (5-7). Other RET alterations like RET mutations are also common in inherited and sporadic medullary thyroid cancer, and other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (8-12) adding >110,000 cases yearly worldwide (13).<\/span><\/p>\n

Analyzing the tumors by sending a tissue sample from a tumor biopsy, or by sending a blood sample for a circulating cell-free DNA (cfDNA) test to a laboratory, to check for specific genetic alterations is the only way to detect cancer drivers like RET. If the test result is positive for a RET fusion or mutation of the RET gene, this information can help to identify effective treatment and clinical research options.<\/span>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” offset=”vc_col-xs-12″][image_with_animation image_url=”292″ image_size=”full” animation_type=”entrance” animation=”None” animation_movement_type=”transform_y” hover_animation=”none” alignment=”” border_radius=”10px” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#ffffff” scene_position=”center” top_padding=”2%” bottom_padding=”3%” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” gradient_type=”default” shape_type=””][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text css=”” text_direction=”default”][\/vc_column_text][split_line_heading animation_type=”line-reveal-by-space” font_style=”h3″ text_color=”#111c4e” line_reveal_by_space_text_effect=”none” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”Treatments for RET-Positive Cancer” text_direction=”default”][\/split_line_heading][divider line_type=”Small Line” line_alignment=”default” line_thickness=”4″ divider_color=”extra-color-1″ custom_line_width=”75″][divider line_type=”No Line” custom_height=”20″][vc_column_text css=”” text_direction=”default”]Currently selpercatinib (Retevmo) and pralsetinib (Gavreto) are the two FDA-approved RET-inhibitors that selectively target the RET protein. These treatments showed great benefit and durable responses in most patients but unfortunately within 1-3 years, many patients become resistant to the therapies and the cancer progress again (3, 12-13). Finding new therapies that prevent resistance or effective treatment option for RET patients who become resistant to selpercatinib and pralsetinib are crucial unmeet needs. Read more about RET lung cancer treatment options<\/a>.[\/vc_column_text][divider line_type=”No Line” custom_height=”20″][split_line_heading animation_type=”line-reveal-by-space” font_style=”h3″ text_color=”#111c4e” line_reveal_by_space_text_effect=”none” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”Resistance in RET-Positive Cancer Treatment” text_direction=”default”][\/split_line_heading][divider line_type=”Small Line” line_alignment=”default” line_thickness=”4″ divider_color=”extra-color-1″ custom_line_width=”75″][divider line_type=”No Line” custom_height=”20″][vc_column_text css=”” text_direction=”default”]Targeted cancer therapies can be very effective in eliminating cancer cells, but unfortunately some tumor cells may escape the effect of the treatment and survive. The surviving cells are able to proliferate and drive tumor growth.<\/p>\n

RET targeted therapies have shown promise in treating RET cancer. These medications specifically target the abnormal RET proteins, slowing cancer progression and improving patient outcomes. However, despite initial success, some patients develop resistance to these cancer treatments over time. Read more about RET lung cancer treatment resistance<\/a>.[\/vc_column_text][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_direction_desktop=”default” column_element_spacing=”default” desktop_text_alignment=”default” tablet_text_alignment=”default” phone_text_alignment=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_backdrop_filter=”none” column_shadow=”none” column_border_radius=”none” column_link_target=”_self” overflow=”visible” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][split_line_heading animation_type=”line-reveal-by-space” font_style=”h3″ text_color=”#111c4e” line_reveal_by_space_text_effect=”none” content_alignment=”default” mobile_content_alignment=”inherit” link_target=”_self” text_content=”About RET-Positive Cancer” text_direction=”default”][\/split_line_heading][divider line_type=”Small Line” line_alignment=”default” line_thickness=”4″ divider_color=”extra-color-1″ custom_line_width=”75″][divider line_type=”No Line” custom_height=”20″][vc_column_text css=”” text_direction=”default”]Those more likely to have RET positive lung cancer are:[\/vc_column_text]

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