{"id":4501,"date":"2026-02-17T08:56:43","date_gmt":"2026-02-17T13:56:43","guid":{"rendered":"https:\/\/happylungsproject.org\/?p=4501"},"modified":"2026-03-02T10:52:34","modified_gmt":"2026-03-02T15:52:34","slug":"positive-results-for-selpercatinib-for-early-stage-ret-lung-cancer","status":"publish","type":"post","link":"https:\/\/happylungsproject.org\/positive-results-for-selpercatinib-for-early-stage-ret-lung-cancer\/","title":{"rendered":"Positive Results for Selpercatinib for Early Stage-RET Lung Cancer"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; row_position_desktop=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; flex_gap_desktop=&#8221;10px&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;padding-3-percent&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; flex_gap_desktop=&#8221;10px&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color=&#8221;#f68d28&#8243; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; font_color=&#8221;#ffffff&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;10px&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221; column_padding_type=&#8221;default&#8221; gradient_type=&#8221;default&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]\n<p data-pm-slice=\"1 1 []\">Eli Lilly and Company announced positive results from the Phase 3 LIBRETTO-432 clinical trial evaluating Retevmo\u00ae (selpercatinib) as adjuvant therapy versus placebo in early-stage (II\u2013IIIA) RET fusion-positive lung cancer.<\/p>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; text_align=&#8221;left&#8221; row_position=&#8221;default&#8221; row_position_tablet=&#8221;inherit&#8221; row_position_phone=&#8221;inherit&#8221; overflow=&#8221;visible&#8221; pointer_events=&#8221;all&#8221;][vc_column_inner column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; flex_gap_desktop=&#8221;10px&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; overflow=&#8221;visible&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]Selpercatinib showed a statistically significant improvement in event-free survival (EFS) as adjuvant therapy in patients with early-stage RET fusion-positive NSCLC. Overall survival trended positively (data immature), and safety was consistent with prior trials.<\/p>\n<p>Detailed results will be shared at an upcoming medical meeting.<\/p>\n<p>These results also reinforce the importance of genomic testing at diagnosis. Identifying RET fusions helps ensure patients can access personalized treatments designed for their cancer.\u00a0Advances like this bring hope and move us closer to better outcomes for people living with early stage RET-positive lung cancer.<\/p>\n<p>Read more:\u00a0<a href=\"https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-retevmo-selpercatinib-delivers-substantial-event-free\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/investor.lilly.com\/news-releases\/news-release-details\/lillys-retevmo-selpercatinib-delivers-substantial-event-free&amp;source=gmail&amp;ust=1771422310124000&amp;usg=AOvVaw0hVmSfi3_mtoOyq2HkJJ8q\">https:\/\/investor.lilly.<wbr \/>com\/news-releases\/news-<wbr \/>release-details\/lillys-<wbr \/>retevmo-selpercatinib-<wbr \/>delivers-substantial-event-<wbr \/>free<\/a><\/p>\n<p>LIBRETTO-432 clinical trial:\u00a0<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04819100\" target=\"_blank\" rel=\"noopener\" data-saferedirecturl=\"https:\/\/www.google.com\/url?q=https:\/\/clinicaltrials.gov\/study\/NCT04819100&amp;source=gmail&amp;ust=1771422310124000&amp;usg=AOvVaw3vl8bVw0Arw1sZAx1h2BP0\">https:\/\/clinicaltrials.<wbr \/>gov\/study\/NCT04819100<\/a><\/p>\n<a class=\"nectar-button n-sc-button large accent-color regular-button\"  href=\"https:\/\/happylungsproject.org\/current-clinical-trials\/\" data-color-override=\"false\" data-hover-color-override=\"false\" data-hover-text-color-override=\"#fff\"><span>View all RET clinical trials<\/span><\/a>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>Eli Lilly and Company announced positive results from the Phase 3 LIBRETTO-432 clinical trial evaluating Retevmo\u00ae (selpercatinib) as adjuvant therapy versus placebo in early-stage (II\u2013IIIA) RET fusion-positive lung cancer.<\/p>\n","protected":false},"author":15,"featured_media":2623,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,20],"tags":[],"class_list":{"0":"post-4501","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-clinical-trials","8":"category-treatment"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Positive results for selpercatinib for early stage-RET lung cancer<\/title>\n<meta name=\"description\" content=\"Eli Lilly announced positive results LIBRETTO-432 clinical trial, Retevmo\u00ae (selpercatinib) in early-stage RET fusion-positive lung cancer.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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Project"},"image":{"@id":"https:\/\/happylungsproject.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/thehappylungsproject","https:\/\/www.instagram.com\/thehappylungsproject\/"]},{"@type":"Person","@id":"https:\/\/happylungsproject.org\/#\/schema\/person\/7f7dfd38ae877d303fc9831b49693d4b","name":"Irene Guijarro Munoz","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/happylungsproject.org\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/b203420602dc287c938d2e2de2a2da59b7a2f94264288a3f345af4be6737c07a?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b203420602dc287c938d2e2de2a2da59b7a2f94264288a3f345af4be6737c07a?s=96&d=mm&r=g","caption":"Irene Guijarro Munoz"},"description":"Irene Guijarro Munoz, Director of Research Irene Guijarro Munoz joined the Happy Lungs Project (HLP) as Director of Research in 2022. 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