{"id":2084,"date":"2023-10-10T09:29:29","date_gmt":"2023-10-10T13:29:29","guid":{"rendered":"https:\/\/happylungsproject.org\/?p=2084"},"modified":"2026-03-02T10:53:34","modified_gmt":"2026-03-02T15:53:34","slug":"exciting-preclinical-results-about-vepafestinib","status":"publish","type":"post","link":"https:\/\/happylungsproject.org\/exciting-preclinical-results-about-vepafestinib\/","title":{"rendered":"Exciting Preclinical Results About Vepafestinib"},"content":{"rendered":"[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221; column_shadow=&#8221;none&#8221; column_border_radius=&#8221;none&#8221; column_link_target=&#8221;_self&#8221; column_position=&#8221;default&#8221; gradient_direction=&#8221;left_to_right&#8221; overlay_strength=&#8221;0.3&#8243; width=&#8221;1\/1&#8243; tablet_width_inherit=&#8221;default&#8221; animation_type=&#8221;default&#8221; bg_image_animation=&#8221;none&#8221; border_type=&#8221;simple&#8221; column_border_width=&#8221;none&#8221; column_border_style=&#8221;solid&#8221;][divider line_type=&#8221;No Line&#8221; custom_height=&#8221;20&#8243;][vc_column_text css=&#8221;&#8221; text_direction=&#8221;default&#8221;]\n<h2><b>New published study with exciting preclinical results about the second generation RET inhibitor vepafestinib\u00a0(TAS0953\/HM06).\u00a0<\/b><\/h2>\n<p><b>Vepafestinib\u00a0showed\u00a0selectivity against most common RET resistance mutations<\/b> including the\u00a0RETG810 mutation, and superior pharmacokinetic properties in the brain. The compound showed activity\u00a0in an intracranial model of RET-driven cancer. The compound is currently being tested clinically in a phase 1-2 study (<a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04683250\">https:\/\/clinicaltrials.gov\/study\/NCT04683250<\/a>).<\/p>\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37743366\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37743366\/<\/a><\/p>\n<p><a href=\"https:\/\/happylungsproject.org\/current-treatment-options-for-ret-lung-cancer\/\">Learn more about RET-positive lung cancer treatment options<\/a>.[\/vc_column_text][\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"<p>[vc_row type=&#8221;in_container&#8221; full_screen_row_position=&#8221;middle&#8221; column_margin=&#8221;default&#8221; column_direction=&#8221;default&#8221; column_direction_tablet=&#8221;default&#8221; column_direction_phone=&#8221;default&#8221; scene_position=&#8221;center&#8221; text_color=&#8221;dark&#8221; text_align=&#8221;left&#8221; row_border_radius=&#8221;none&#8221; row_border_radius_applies=&#8221;bg&#8221; overflow=&#8221;visible&#8221; overlay_strength=&#8221;0.3&#8243; gradient_direction=&#8221;left_to_right&#8221; shape_divider_position=&#8221;bottom&#8221; bg_image_animation=&#8221;none&#8221; shape_type=&#8221;&#8221;][vc_column column_padding=&#8221;no-extra-padding&#8221; column_padding_tablet=&#8221;inherit&#8221; column_padding_phone=&#8221;inherit&#8221; column_padding_position=&#8221;all&#8221; column_element_direction_desktop=&#8221;default&#8221; column_element_spacing=&#8221;default&#8221; desktop_text_alignment=&#8221;default&#8221; tablet_text_alignment=&#8221;default&#8221; phone_text_alignment=&#8221;default&#8221; background_color_opacity=&#8221;1&#8243; background_hover_color_opacity=&#8221;1&#8243; column_backdrop_filter=&#8221;none&#8221;&#8230;<\/p>\n","protected":false},"author":15,"featured_media":2083,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,20],"tags":[],"class_list":{"0":"post-2084","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-research","8":"category-treatment"},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - 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